Special items given by the D4, the D100, 1-pip Dice Rooms, and 6-pip Dice Rooms count as 'seen' special items.Isaac's The D6 doesn't count as a 'seen' special item, as it is directly given to him when the run starts.Special items have a chance of being re-rolled depending on how many special items have been seen during the run: When Isaac enters a room with an item in it, items are selected out of certain item pools depending upon the current room.
The list of special items is as follows:.The system was removed entirely in Repentance, with the item weight mechanic expanded to compensate. If the player sees a special item, even if the player has Curse of the Blind, subsequent special items have a chance of being rerolled rather than being presented to Isaac, decreasing the likelihood of obtaining multiple special items on one run. Special items are items in the game that are considered stronger than normal by the developers.
